|
rs750814369
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the variant genotypes of p21 Ser31Arg and p27 C-79T were individually associated with a significantly increased risk of HCC, but no associations were observed for other variant genotypes.
|
23034899 |
2013 |
|
rs6940552
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We designed a case-control study of 1300 HBV-positive HCC patients, 1344 HBV persistent carriers and, 1344 HBV natural clearance subjects to test the associations of three ZNRD1 eQTLs SNPs (rs3757328, rs6940552 and, rs9261204) in ZNRD1-AS1 with the risk of both chronic HBV infection and HCC.
|
25110835 |
2015 |
|
rs6940552
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found consistently significant associations between the ZNRD1-AS1 rs6940552 and rs9261204 SNPs with an increased risk of HCC (additive genetic model: adjusted OR = 1.16, 95% CI = 1.03-1.32 for rs6940552; adjusted OR =1.20, 95% CI = 1.06-1.35 for rs9261204) and found a borderline association between rs3757328 and HCC risk.
|
27286450 |
2016 |
|
rs9261204
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found consistently significant associations between the ZNRD1-AS1 rs6940552 and rs9261204 SNPs with an increased risk of HCC (additive genetic model: adjusted OR = 1.16, 95% CI = 1.03-1.32 for rs6940552; adjusted OR =1.20, 95% CI = 1.06-1.35 for rs9261204) and found a borderline association between rs3757328 and HCC risk.
|
27286450 |
2016 |
|
rs9261204
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We designed a case-control study of 1300 HBV-positive HCC patients, 1344 HBV persistent carriers and, 1344 HBV natural clearance subjects to test the associations of three ZNRD1 eQTLs SNPs (rs3757328, rs6940552 and, rs9261204) in ZNRD1-AS1 with the risk of both chronic HBV infection and HCC.
|
25110835 |
2015 |
|
rs3757328
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found consistently significant associations between the ZNRD1-AS1 rs6940552 and rs9261204 SNPs with an increased risk of HCC (additive genetic model: adjusted OR = 1.16, 95% CI = 1.03-1.32 for rs6940552; adjusted OR =1.20, 95% CI = 1.06-1.35 for rs9261204) and found a borderline association between rs3757328 and HCC risk.
|
27286450 |
2016 |
|
rs3757328
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Logistic regression analyses in additive genetic model showed that variant alleles of all the three SNPs increased host HCC risk, whereas variant allele of rs3757328 was associated with HBV clearance.
|
25110835 |
2015 |
|
rs132770
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Firstly, the associations of XRCC6 promoter T-991C (rs5751129), promoter G-57C (rs2267437), promoter A-31G (rs132770), and intron-3 (rs132774) polymorphisms with HCC risk in this Taiwanese population were evaluated.
|
23393345 |
2013 |
|
rs2267437
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Firstly, the associations of XRCC6 promoter T-991C (rs5751129), promoter G-57C (rs2267437), promoter A-31G (rs132770), and intron-3 (rs132774) polymorphisms with HCC risk in this Taiwanese population were evaluated.
|
23393345 |
2013 |
|
rs5751129
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Firstly, the associations of XRCC6 promoter T-991C (rs5751129), promoter G-57C (rs2267437), promoter A-31G (rs132770), and intron-3 (rs132774) polymorphisms with HCC risk in this Taiwanese population were evaluated.
|
23393345 |
2013 |
|
rs132774
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Firstly, the associations of XRCC6 promoter T-991C (rs5751129), promoter G-57C (rs2267437), promoter A-31G (rs132770), and intron-3 (rs132774) polymorphisms with HCC risk in this Taiwanese population were evaluated.
|
23393345 |
2013 |
|
rs16855458
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that a significantly reduced risk for HCC was associated with XRCC5 rs16855458 [odds ratio (OR)=0.59; 95% confidence interval (CI)=0.43-0.81; CA+AA versus CC] and a significantly increased risk for HCC was associated with XRCC5 rs9288516 (OR=2.02; 95% CI=1.42-2.86; TA+AA versus TT) even after Bonferroni correction (Pcorrected=0.026 and 0.002, respectively).
|
21304054 |
2011 |
|
rs80309960
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the role of genetic polymorphisms at XRCC4 codon 247 (rs3734091, XRCC4P) and XRCC5 codon 180 (rs80309960, XRCC5P) in liver cancer (hepatocellular carcinoma) caused by aflatoxin B1 (AFB1).
|
23788213 |
2013 |
|
rs9288516
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that a significantly reduced risk for HCC was associated with XRCC5 rs16855458 [odds ratio (OR)=0.59; 95% confidence interval (CI)=0.43-0.81; CA+AA versus CC] and a significantly increased risk for HCC was associated with XRCC5 rs9288516 (OR=2.02; 95% CI=1.42-2.86; TA+AA versus TT) even after Bonferroni correction (Pcorrected=0.026 and 0.002, respectively).
|
21304054 |
2011 |
|
rs1805377
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The SNP of XRCC4 rs1805377 was significantly associated with decreased risk of HCC development (OR, 0.592; p=0.028) and improved overall survival of patients with HCC (median survival time (MST) of 48, 72, and 89 months for the AA, AG, and GG genotypes, respectively; p=0.044).
|
22659345 |
2012 |
|
rs1805377
|
|
|
0.020 |
GeneticVariation |
BEFREE |
With TaqMan real-time PCR, the results showed that no significant association between XRCC4 (rs1</span>805377) and ATF6 (rs2070150) and risk of HCC in the Thai population.
|
26925648 |
2016 |
|
rs28383151
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These individuals with the genotypes of rs283</span>83151 A alleles (rs28383151-GA/AA), compared with the homozygote of rs28383151 G alleles (rs28383151-GG), faced increasing risk of HCC (odds ratio [OR]: 2.17; 95% confidence interval: 1.77-2.67).
|
23390017 |
2013 |
|
rs3734091
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the role of genetic polymorphisms at XRCC4 codon 247 (rs3734091, XRCC4P) and XRCC5 codon 180 (rs80309960, XRCC5P) in liver cancer (hepatocellular carcinoma) caused by aflatoxin B1 (AFB1).
|
23788213 |
2013 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
On univariate analysis, a statistically significant association was found between risk of HCC and XRCC1 399Arg/Gln genotype (odd ratio [OR] = 1.88; 95% CI, 1.04-3.43), which was confirmed after adjusting by sex (OR = 1.94; 95% CI, 1.04-3.63).
|
28058700 |
2017 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests the participation of XRCC1 Arg399Gln is a genetic susceptibility for hepatocellular cancer in Asians and breast cancer in Indians.
|
24205095 |
2013 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our analysis suggested that the variant genotypes of the XRCC1 Arg399Gln gene were associated with a significantly increased risk of HCC in a co-dominant model (Arg/Gln vs. Arg/Arg, odd ratios [OR] 1.39, 95 % confidence interval [CI] 1.08-1.79; Gln/Gln vs. Arg/Arg, OR 1.26, 95 % CI 1.04-1.52) and a dominant model (Arg/Gln + Gln/Gln vs. Arg/Arg OR 1.36, 95 % CI 1.07-1.72), whereas no association was observed in the recessive model (Gln/Gln vs. Arg/Gln + Arg/Arg, OR 1.05, 95 % CI 0.91-1.21).
|
24390232 |
2014 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interestingly, the risk for HCC was further enhanced by 35.96 (95% CI = 11.64-110.91; P < 0.001) and 5.28 times (95% CI = 2.81-9.09; P < 0.001) when the genotype Arg280His was found in association with Arg194Trp and Arg399Gln, respectively.
|
19194663 |
2009 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The XRCC1 rs25487 polymorphisms are prognostic for HCC patients receiving TACE.
|
26918371 |
2016 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We explored the association between 4 XRCC1 (Arg194Trp and Arg399Gln) and XPD (Asp312Asn and Lys751Gln) polymorphisms with the development and prognosis of hepatocellular carcinoma (HCC).
|
24938468 |
2014 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The XRCC1 Arg194Trp and Arg399Gln polymorphisms are not associated with HCC risk.
|
22919255 |
2012 |